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SCGN / Secretagogin Antibody [SCGN/7325]

Additional information

Catalog Number: 10590-MSM5
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
10590-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
10590-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
10590-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
SCGN Antibody in SDS-PAGE

SCGN Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified SCGN Mouse Monoclonal Antibody (SCGN/7325). Confirmation of Purity and Integrity of Antibody.

Secretagogin (SCGN) Antibody in Immunohistochemistry (IHC (P))

Secretagogin (SCGN) Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human pancreas stained with Secretagogin Mouse Monoclonal Antibody (SCGN/7325). Inset: PBS instead of primary antibody; secondary only negative control.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
SCGN/7325
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Cytoplasm, Secreted
Gene Name
SCGN
Positive Control
Human pancreas, brain or gastrointestinal tract.
Immunogen
Recombinant fragment (around aa100-276) of human SCGN protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Key References
  • Dong, Y., et al. 2020. Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A. Oncol. Lett. 19: 2223-2230.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
10590
SwissProt
O76038
Chromosome Location
6p22.2
Mol. Weight of Antigen
32kDa
Alternate Names
Secretagogin, Calbindin like; CALBL; DJ501N12.8; SECRET; Secretagogin EF hand calcium binding protein; SEGN; Setagin

Summary

SCGN, also known as Secretagogin, CALBL, setagin or SECRET, is a 276 amino acid cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. Expressed in a variety of tissues including stomach, thyroid, colon, brain and neuroendocrine cells, SCGN is thought to be involved in cell proliferation and KCl (potassium chloride)-mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication.

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