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SCGN / Secretagogin Antibody [SCGN/7325]

In Stock
Catalog Number Formulation Size Price
10590-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
10590-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
10590-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

SCGN, also known as Secretagogin, CALBL, setagin or SECRET, is a 276 amino acid cytoplasmic protein that contains six EF-hand domains and is related to the calicium-binding proteins Calretinin and Calbindin D28K. Expressed in a variety of tissues including stomach, thyroid, colon, brain and neuroendocrine cells, SCGN is thought to be involved in cell proliferation and KCl (potassium chloride)-mediated calcium flux events. Through its interaction with KCl and its subsequent ability to modulate calcium storage pools within the cell, SCGN may function to negatively control growth and differentiation rates and, thus, indirectly inhibit cell replication.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2 / Kappa
Cellular Localization
Cytoplasm, Secreted
Gene Name
Positive Control
Human pancreas, brain or gastrointestinal tract.
Immunogen
Recombinant fragment (around aa100-276) of human SCGN protein (exact sequence is proprietary)
Alternate Names
Secretagogin, Calbindin like; CALBL; DJ501N12.8; SECRET; Secretagogin EF hand calcium binding protein; SEGN; Setagin

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
SCGN/7325
Chromosome Location
6p22.2
Mol. Weight of Antigen
32kDa

Key References

  • Dong, Y., et al. 2020. Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A. Oncol. Lett. 19: 2223-2230.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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