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Recombinant TCL1 (T-Cell Marker) Antibody [TCL1/2747R]

Additional information

Catalog Number: 8115-RBM3
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
8115-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8115-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8115-RBM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant TCL1 (T-Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with TCL1 Recombinant Rabbit Monoclonal Antibody (TCL1/2747R).

Recombinant TCL1 (T-Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Tonsil stained with TCL1 Recombinant Rabbit Monoclonal Antibody (TCL1/2747R).

TCL1 Antibody in Western Blot (WB)

TCL1 Antibody in Western Blot (WB)

Western Blot Analysis of Raji and Ramos cell lysates using TCL1 Recombinant Rabbit Monoclonal Antibody (TCL1/2747).

TCL1A Antibody in SDS-PAGE

TCL1A Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified T-cell leukemia/lymphoma protein 1A Recombinant Rabbit Monoclonal Antibody (TCL1/2747R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
TCL1/2747R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus
Gene Name
TCL1A
Positive Control
Ramos or Raji cells. Tonsil or T-cell Lymphoma.
Immunogen
Recombinant fragment (around aa2-109) of the human TCL1 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
8115
SwissProt
P56279
Chromosome Location
14q32.13
Mol. Weight of Antigen
13.46kDa
Alternate Names
T-cell leukemia/lymphoma protein 1A, TCL1

Summary

T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.

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