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Recombinant Ribonucleotide Reductase M1 / RRM1 Antibody [rRRM1/9409]

Additional information

Catalog Number: 6240-MSM4
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
6240-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6240-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6240-MSM4-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Ribonucleotide Reductase M1 Antibody in Western Blot (WB)

Ribonucleotide Reductase M1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Skin, Human Skeletal muscle, A549 and K-562 lysates using Ribonucleotide Reductase M1 Recombinant Mouse Monoclonal Antibody (rRRM1/9409).

RRM1 Antibody in SDS-PAGE

RRM1 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified RRM1 Recombinant Mouse Recombinant Monoclonal Antibody (rRRM1/9409). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rRRM1/9409
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cytoplasm
Gene Name
RRM1
Positive Control
Human breast, lung or colon carcinoma tissue. Human Skeletal muscle, Human Skin, A549 or K-562
Immunogen
Recombinant fragment (around aa700-800) of the human RRM1 protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6240
SwissProt
P23921
Chromosome Location
11p15.4
Mol. Weight of Antigen
90.07kDa
Alternate Names
Ribonucleoside-diphosphate reductase large subunit, PEOB6|R1|RIR1|RR1

Summary

Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.

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