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Formalin-fixed, paraffin-embedded human Stomach Carcinoma stained with MUC1 Rabbit Recombinant Monoclonal Antibody (MUC1/2818R).
Formalin-fixed, paraffin-embedded human Colon stained with MUC1 Rabbit Recombinant Monoclonal Antibody (MUC1/2818R).
Western Blot Analysis of Human kidney and Human Lung tissue lysates using MUC-1 Recombinant Rabbit Monoclonal Antibody (MUC1/2818R).
Western blot analyses of human lung, mouse lung, rat lung, hamster lung, guinea pig lung and rabbit lung tissue lysates using MUC-1 Recombinant Rabbit Monoclonal Antibody (MUC1/2818R).
SDS-PAGE Analysis of Purified MUC1 Rabbit Recombinant Monoclonal Antibody (MUC1/2818R). Confirmation of Purity and Integrity of Antibody.
| Document Name | |
|---|---|
| Datasheet | Download Here |
| Material Safety Data Sheet | Download Here |
| Applications | Tested Dilutions | Protocol | Note |
|---|---|---|---|
| Immunohistochemistry (IHC) | 1-2ug/ml | IHC Protocol | 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes |
| Western Blot (WB) | 2-4ug/ml | Western Blot Protocol |
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This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in 90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
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