Recombinant HLA-DR (MHC II) Antibody [MSVA-470R]

Summary

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides(CLIP) from an antigen binding groove in MHC II-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen bind-ing. Accumulating in endosomal / lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR,-DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules playa central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane-anchored heavy chain and a light chain (b-2-Microglobulin).Polymorphisms yield hundreds of HLA-B and -C alleles.