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Recombinant Glutamine Synthetase / GLUL Antibody [GLUL/12954R]

Additional information

Catalog Number: 2752-RBM42
Host:

Reactivity:

, ,

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2752-RBM42-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2752-RBM42-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2752-RBM42-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Glutamine Synthetase Antibody in Western Blot (WB)

Glutamine Synthetase Antibody in Western Blot (WB)

Western blot analysis of brain tissue lysates in several species using Glutamine Synthetase Recombinant Rabbit Monoclonal Antibody (GLUL/12954R).

Glutamine Synthetase / GLUL Antibody in SDS-PAGE

Glutamine Synthetase / GLUL Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified GLUL Recombinant Rabbit Monoclonal Antibody (GLUL/12954R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Rabbit Monoclonals, Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human, Mouse, Rat
Clone
GLUL/12954R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Mitochondrion
Gene Name
GLUL
Positive Control
Y79 cells. Human brain, placenta, testis or stomach. Mouse Brain, Rat Brain, Human Liver, Mouse Liver or Rat Liver
Immunogen
Recombinant fragment (around aa 100-200) of human GLUL protein (exact sequence is proprietary)
Expression System
CHO
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Additional information

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Reactivity:

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Host:

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351).
Key References
  • Min, Q., et al. 2019. β-catenin and yes-associated protein 1 cooperate in hepatoblastoma pathogenesis. Am. J. Pathol. 189: 1091-1104.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2752
SwissProt
P15104
Chromosome Location
1q25.3
Mol. Weight of Antigen
42kDa
Alternate Names
Glutamine synthetase, Glutamate, ammonia ligase, Palmitoyltransferase GLUL, cell proliferation-inducing protein 59; GLUL; Glutamate ammonia ligase; GS; PIG43; PIG59; Glutamate decarboxylase; glutamine synthase; Glutamine synthetase; glutamine synthetase I; Proliferation inducing protein 43; GLNA; GLNS

Summary

Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.

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