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Recombinant CD40 / TNFRSF5 Antibody [r11E9]

Additional information

Catalog Number: 958-MSM15
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
958-MSM15-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
958-MSM15-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
958-MSM15-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD40 Antibody in Immunohistochemistry (IHC (P))

CD40 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human tonsil stained with CD40 Recombinant Mouse Monoclonal Antibody (r11E9). Inset: PBS instead of primary antibody; secondary only negative control.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
r11E9
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
CD40
Positive Control
Human spleen, lymph node or tonsil.
Immunogen
Prokaryotic recombinant fusion protein corresponding to the entire external domain of the CD40 molecule
Expression System
CHO
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).
Key References
  • van den Oord, J J et al. “CD40 is a prognostic marker in primary cutaneous malignant melanoma.” The American journal of pathology vol. 149,6 (1996): 1953-61.
  • Carbone, A et al. “Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines.” Blood vol. 85,3 (1995): 780-9.
  • Carbone, A et al. “CD40 antigen expression on Reed-Sternberg cells. A reliable diagnostic tool for Hodgkin's disease.” The American journal of pathology vol. 146,3 (1995): 780-1.
  • Hollenbaugh, D et al. “Expression of functional CD40 by vascular endothelial cells.” The Journal of experimental medicine vol. 182,1 (1995): 33-40. doi:10.1084/jem.182.1.33
  • O'Grady, J T et al. “CD40 expression in Hodgkin's disease.” The American journal of pathology vol. 144,1 (1994): 21-6.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
958
SwissProt
P25942
Chromosome Location
20q12-q13.2
Mol. Weight of Antigen
43kDa
Alternate Names
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5

Summary

The CD40 antigen is a single chain glycoprotein with a calculated molecular weight of 27 kD. It is known to be a member of the tumor necrosis factor/nerve growth factor superfamily and shows a significant homology to the Hodgkin’s disease-associated antigen, CD30. The precise function of the CD40 antigen is unknown, but it appears to be involved in the transduction of regulatory signals for cellular functions such as B cell proliferation and differentiation. It is also important in the prevention of apoptosis of germinal centre B cells. The CD40 antigen is found on mature B cells (except plasma cells), interdigitating reticulum cells and follicular dendritic cells.

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