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Recombinant CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody [rLPFS2/1611]

Additional information

Catalog Number: 939-MSM3
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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Recombinant CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611).

Recombinant CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - Image 2

SDS-PAGE Analysis of Purified CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611). Confirmation of Integrity and Purity of Antibody.

Recombinant CD27 (Tumor Necrosis Factor Receptor Superfamily 7) Antibody - Image 3

Flow Cytometric Analysis of Ramos cells using CD27 Recombinant Mouse Monoclonal Antibody (rLPFS2/1611) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

  • IF
  • IHC
  • WB
  • Flow
In Stock
Catalog Number Formulation Availability Size Price
939-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
Trial Size
In Stock
20ug
$259.00
Trial Size Available In-Stock
939-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
In Stock
100ug
$559.00
In-Stock
939-MSM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
Carrier-Free
In Stock
100ug
$559.00
Carrier-Free Available In-Stock
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunofluorescence, Immunohistochemistry, Western Blot, Flow
Species Reactivity
Human
Clone
rLPFS2/1611
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CD27
Positive Control
Ramos cells. Human peripheral blood lymphocytes. Human tonsil and lymph node.
Immunogen
Recombinant human CD22 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells (PubMed:28011863). The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells (PubMed:28011863). Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory (PubMed:38354704). In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis (By similarity). Negatively regulates the function of Th2 lymphocytes in the adipose tissue (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
939
SwissProt
P26842
Chromosome Location
12p13.31
Mol. Weight of Antigen
29.14kDa
Alternate Names
CD27 antigen, S152|S152. LPFS2|T14|TNFRSF7|Tp55

Summary

Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27. It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NFkB and SAPK/JNK and induces apoptosis.

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