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Recombinant CD200 Receptor 1 (CD200R1) / OX2 Antibody [CD200R1/9919R]

Additional information

Catalog Number: 131450-RBM16
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
131450-RBM16-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
131450-RBM16-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
131450-RBM16-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD200R1 / OX-2 Antibody in Immunohistochemistry (IHC (P))

CD200R1 / OX-2 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human renal cell carcinoma stained with CD200R1 Recombinant Rabbit Monoclonal Antibody (CD200R1/9919R). Inset: PBS instead of primary antibody; secondary only negative control.

CD200R1 / OX-2 Antibody in SDS-PAGE

CD200R1 / OX-2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified CD200R1 Recombinant Rabbit Monoclonal Antibody (CD200R1/9919R). Confirmation of Purity and Integrity of Antibody.

CD200R1 / OX-2 Antibody in Western Blot (WB)

CD200R1 / OX-2 Antibody in Western Blot (WB)

Western blot analysis of A549 cell lysate using CD200R1 Recombinant Rabbit Monoclonal Antibody (CD200R1/9919R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
CD200R1/9919R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
CD200R1
Positive Control
Human spleen, tonsil, lymph node or kidney. Daudi or U937 cells. A549
Immunogen
Recombinant fragment (around aa80-221) of the human CD200R1 protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
131450
SwissProt
Q8TD46
Chromosome Location
3q13.2
Mol. Weight of Antigen
39.04kDa
Alternate Names
Cell surface glycoprotein CD200 receptor 1, CD200R|HCRTR2|MOX2R|OX2R

Summary

OX2 (CD200, MOX2), a member of the immunoglobulin superfamily (IgSF), is a 248 residue cell surface glycoprotein that is expressed in lymphoid cells, neurons and endothelium. OX2 receptor (OX2R) is a membrane protein with up to 70% of its weight derived from N-linked glycosylation; it is primarily expressed in lymphoid and neuronal tissue. Phylogenetic analysis of OX2R with respect to other leukocyte IgSF glycoproteins suggests that OXR2 and OX2 share a common ancestral protein. The cytoplasmic portion of OX2R contains NPXY motifs that are known to interact with PTB/PID binding domains. The interaction between OX2 and OX2R may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue.

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