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Proteolipid Protein / Myelin PLP Antibody [PLP1/4259]

In Stock
Catalog Number Formulation Size Price
5354-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
5354-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
5354-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Proteolipid Protein / Myelin PLP Antibody

Formalin-fixed, paraffin-embedded human brain stained with Myelin PLP Mouse Monoclonal Antibody (PLP1/4259).

Proteolipid Protein / Myelin PLP Antibody - Image 2

SDS-PAGE Analysis of Purified Myelin PLP Mouse Monoclonal Antibody (PLP1/4259). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Proteolipid protein (PLP) is the major myelin protein of the CNS and plays an important role in the formation and maintenance of myelin. PLP may play a role in the compaction and stabilization of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in PLP gene can lead to dysmyelinating diseases. Clone PLP1/4259 is used in the detection of PLP by various analysis methods.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Cow, Human, Mouse, Rat, Tenerife Lizard
Research Areas
Cardiovascular
Isotype / Light Chain
IgG2a /
Cellular Localization
Cell membrane, Myelin membrane
Gene Name
PLP1
Positive Control
Human brain tissue.
Immunogen
Synthetic peptide GRGTKF that recognizes the C terminal region (aa272-277) of myelin proteolipid protein.
Alternate Names
Myelin proteolipid protein, Lipophilin, Myelin proteolipid protein, PLP, Lipophilin, PLP1, HLD1, SPG2, PMD, Major myelin proteolipid protein (MMPL), DM20

Database Links

Entrez Gene ID
5354
SwissProt
P60201

Additional Information

Clone
PLP1/4259
Chromosome Location
Xq22.2
Mol. Weight of Antigen
23-25kDa

Related Antibodies

View All PLP1 Antibodies

Functions

  • This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.

Key References

  • Van der Goesa, Annette, et al. (2000) The Role of Anti-Myelin (Auto)-Antibodies in the Phagocytosis of Myelin by Macrophages. Journal of Neuroimmunology, 101, 61-67.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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