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Plasma Cell Marker Antibody [LIV3G11; same as 7B18]

In Stock
Catalog Number Formulation Size Price
MSM1-47-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MSM1-47-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MSM1-47-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

It recognizes an intra-cytoplasmic antigen, which shows a very high degree of specificity for plasma cells. This antigen is present in normal as well as neoplastic plasma cells. Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity. Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes. The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes. Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement. This MAb superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections. It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma. Note that this MAb is not suitable for staining frozen tissues.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
N/A
Gene Name
N/A
Positive Control
tonsil or lymph node.
Immunogen
Pancreatic cancer-related mucin
Alternate Names
N/A, N/A, Plasma B cell, Plasmocytes

Database Links

Entrez Gene ID
SwissProt
N/A

Additional Information

Clone
LIV3G11; same as 7B18
Mol. Weight of Antigen
Not Known

Functions

  • N/A

Key References

  • Turley H, Jones M, Erber W, et al.. Journal of Clinical Pathology. 47: 418-422 (1994).
  • Ching CK and Rhodes JM. 1998. Gastroenterology; 95: 137-42.
  • Ching CK and Rhodes JM. 1990. In J Cancer. 45: 1022-7.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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