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Recombinant P-glycoprotein / p170 / MDR1 / CD243 Antibody [MDR1/8986R]

Additional information

Catalog Number: 5243-RBM5
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5243-RBM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5243-RBM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5243-RBM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant P-glycoprotein / p170 / MDR1 / CD243 Antibody

Formalin-fixed, paraffin-embedded human adrenal gland stained with MDR1 Recombinant Rabbit Monoclonal Antibody (MDR1/8986R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

ABCB1 Antibody in SDS-PAGE

ABCB1 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified ATP-dependent translocase ABCB1 Recombinant Rabbit Monoclonal Antibody (MDR1/8986R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
MDR1/8986R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Membrane.
Gene Name
ABCB1
Positive Control
hPBL or Jurkat whole cell lysate. Human adrenal gland.
Immunogen
Recombinant fragment (around aa500-700) of human ABCB1 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Host:

VIEW ALL ANTIBODIES

Other Information

Functions
  • Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218, PubMed:35970996). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218, PubMed:35970996).
Key References
  • Tedder, T.F., et al. 1995. FASEB J. 10: 866-873.
  • Lasky, L.A. 1995. Ann. Rev. Biochem. 64: 113-139.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5243
SwissProt
P08183
Chromosome Location
7q21.12
Mol. Weight of Antigen
170kDa
Alternate Names
ATP-dependent translocase ABCB1, ATP-binding cassette sub-family B member 1, Multidrug resistance protein 1, P-glycoprotein 1, Phospholipid transporter ABCB1, ABC20; ABCB1; ATP-binding cassette sub-family B member 1; CD243; CLCS; Colchicin sensitivity; Doxorubicin resistance; GP170; Multidrug resistance protein 1 (MDR1); P-glycoprotein 1 (PGY1)

Summary

Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.

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