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Melanoma Antigen Family A, 4 / MAGEA4 Antibody [CPTC-MAGEA4-1]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
4103-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4103-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4103-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors, and based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types, but not in normal tissues, with the exception of testis and placenta.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2c / Kappa
Gene Name
Positive Control
HepG2 cell lysate; melanoma, testes and placenta.
Immunogen
Recombinant full-length human MAGEA4 protein
Alternate Names
Melanoma-associated antigen 4, Cancer/testis antigen 1.4, MAGE-4 antigen, MAGE-41 antigen, MAGE-X2 antigen, CT1.4; MAGE-41; MAGE-X2; MAGE4; MAGE4A; MAGE4B; cancer/testis antigen 1.4; Melanoma-associated antigen 4

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CPTC-MAGEA4-1
Chromosome Location
Xq28
Mol. Weight of Antigen
45-50kDa

Functions

  • Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase (PubMed:22842486). Also negatively regulates p53-mediated apoptosis (PubMed:22842486).

Key References

  • Rogner, UC, et al. Genomics., U.S. National Library of Medicine, 10 Oct. 1995.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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