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IL18R1 Antibody [IL18R1/7591]

Additional information

Catalog Number: 8809-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
8809-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8809-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8809-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
IL18R1 Antibody

SDS-PAGE Analysis of Purified IL18R1 Mouse Monoclonal Antibody (IL18R1/7591). Confirmation of Purity and Integrity of Antibody.

IL18R1 Antibody - Image 2

Formalin-fixed, paraffin-embedded human adrenal gland stained with IL18R1 Mouse Monoclonal Antibody (IL18R1/7591). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
IL18R1/7591
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Membrane.
Gene Name
IL18R1
Positive Control
Human lung|leukocytes|liver or thymus.|spleen
Immunogen
Recombinant fragment (around aa1-200) of human IL18R1 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:8626725, PubMed:14528293, PubMed:25261253, PubMed:25500532). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).
Key References
  • Torigoe, K., et al. 1997. Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem. 272: 25737-25742.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
8809
SwissProt
Q13478
Chromosome Location
2q12
Mol. Weight of Antigen
62kDa
Alternate Names
Interleukin-18 receptor 1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, Interleukin-18 receptor alpha, CD218 antigen-like family member A; CDw218a antigen; IL-18R1; IL-1Rrp; IL1 receptor-related protein; Il18ralpha;IL1R-rp; IL1RRP; Interleukin 18 receptor, alpha chain

Summary

Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-Î � production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin s disease cell lines, and does not bind IL-1α or IL-1β. The association of IL-18 to IL-18R leads to activation of NFÎ �B. At present two subunits of IL-18R have been characterized: IL-18Rα and IL-18Rβ. IL-18Rα has been described as the ligand-binding chain and IL-18Rβ as the signal-transduction chain.

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