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ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) Antibody [ICOSL/7700]

Additional information

Catalog Number: 23308-MSM9
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
23308-MSM9-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
23308-MSM9-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
23308-MSM9-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) Antibody

Formalin-fixed, paraffin-embedded human spleen stained with ICOS-L Mouse Monoclonal Antibody (ICOSL/7700). Inset: PBS instead of primary antibody; secondary only negative control.

ICOS-L / ICOS Ligand / B7RP-1 (Immuno-Oncology Target) Antibody - Image 2

Formalin-fixed, paraffin-embedded human colon carcinoma stained with ICOS-L Mouse Monoclonal Antibody (ICOSL/7700). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

ICOSLG Antibody in SDS-PAGE

ICOSLG Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified ICOS ligand Mouse Monoclonal Antibody (ICOSL/7700). Confirmation of Purity and Integrity of Antibody.

ICOS-L Antibody in Western Blot (WB)

ICOS-L Antibody in Western Blot (WB)

Western Blot Analysis of Human Kidney, Human Spleen, K-562, Raji and Ramos lysates using ICOS-L Mouse Monoclonal Antibody (ICOSL/7700).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
ICOSL/7700
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cell Surface. Cytoplasm.
Gene Name
ICOSLG
Positive Control
HL60|HuT78 or HUVEC lysates (WB). Human tonsil tissue (IHC).|U937. Human Kidney, Human Spleen, K-562, Raji or Ramos
Immunogen
Recombinant fragment of human ICOSLG (B7RP-1) protein (around aa 1-300) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Key References
  • Yoshinaga, S.K., et al. 1999. T cell co-stimulation through B7RP-1 and ICOS. Nature 402: 827-832.
  • Cao, Y., et al. 2018. Expression of B7-H2 on CD8+T cells in colorectal cancer microenvironment and its clinical significance. Int Immunopharmacol 56: 128-13.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
23308
SwissProt
O75144
Chromosome Location
21q22.3
Mol. Weight of Antigen
36kDa
Alternate Names
ICOS ligand, B7 homolog 2, B7-like protein Gl50, B7-related protein 1, B7 homolog 2 (B7H2); B7 like protein Gl50; B7 related protein 1 (B7RP1); CD275; CD275 antigen; GL50; ICOS LG; ICOS ligand (ICOSL); Inducible T cell co stimulator ligand; LICOS; Transmembrane protein B7 H2 ICOS ligand

Summary

This MAb recognizes a protein of 36kDa, identified as ICOS-L. It is a ligand for the ICOS receptor that initiates T and B cell proliferation and cytokine secretion. ICOS-L interactions play an essential role in T cell-dependent B cell activation in peripheral lymphoid organs such as spleen and lymph nodes. ICOS-L protein is present in myeloid leukocytes, and by Northern blot there are 2.4, 3.0, and 7.0 kb transcripts in brain, heart, kidney, and liver, with lower expression in colon and thymus, and a 1.1 kb transcript in leukocytes. Tumor necrosis factor alpha (TNFα), granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) enhance its expression. LPS-induced up-regulation of ICOS-L is dependent on the MyD88-dependent signaling pathway.

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