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GC Vitamin D Binding Protein Antibody [VDBP/9980]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
2638-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2638-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2638-MSM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
GC Vitamin D Binding Protein Antibody in Immunohistochemistry (IHC (P))

GC Vitamin D Binding Protein Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human liver stained with GC Vitamin D Binding Protein Mouse Monoclonal Antibody (VDBP/9980). Inset: PBS instead of primary antibody; secondary only negative control.

GC Vitamin D Binding Protein Antibody in Immunohistochemistry (IHC (P))

GC Vitamin D Binding Protein Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human pancreas stained with GC Vitamin D Binding Protein Mouse Monoclonal Antibody (VDBP/9980). Inset: PBS instead of primary antibody; secondary only negative control.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Vitamin D-binding protein (DBP) is a multi-functional serum protein that binds to the plasma membranes of numerous cell types and mediates a variety of cellular functions. The locus of the DBP protein (also known as group-specific component protein or GC) is located at human chromosome 4q13.3. DBP functions in organ-specific transportation of vitamin D and its metabolites to the various target organs of the vitamin D endocrine system. In addition, DBP has immunomodulatory properties and is able to bind to the surface of leukocytes. DBP binds to the plasma membrane through a chondroitin sulfate proteoglycan. DBP serves as a co-chemotactic factor for C5a to enhance the chemotactic activity of C5a. DBP can also bind to globular Actin with high affinity and is involved in the clearance of Actin from the blood. DBP plays an important role in osteoclast differentiation. The diverse cellular functions of DBP require its cell surface binding ability to mediate different biological processes.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cancer, Metabolism, Signal Transduction
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Secreted
Gene Name
GC
Positive Control
Human liver, kidney or pancreas.
Immunogen
Recombinant fragment (around aa 1-200) of human GC protein (exact sequence is proprietary)
Alternate Names
Vitamin D-binding protein, Gc protein-derived macrophage activating factor, Gc-globulin, Group-specific component, Vitamin D-binding protein-macrophage activating factor, DBP/GC; Gc globulin; GRD3; Group specific component vitamin D binding protein; hDBP; VDB; VDBG; VDBP; Vitamin D binding alpha globulin; Vitamin D-binding protein

Database Links

Entrez Gene ID
2638
SwissProt
P02774

Additional Information

Clone
VDBP/9980
Chromosome Location
4q13.3
Mol. Weight of Antigen
53kDa

Related Antibodies

View All GC Antibodies

Functions

  • Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.

Key References

  • Viloria K, et al. Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Cell Rep. 2020;31(11):107761.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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