Printable Datasheet

Folate receptor beta Antibody [FOLR2/13393]

In Stock
Catalog Number Formulation Size Price
2350-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2350-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2350-MSM2-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Isotype / Light Chain
IgG /
Cellular Localization
Cell membrane, Secreted
Gene Name
FOLR2
Positive Control
Expressed in placenta and hematopoietic cells
Immunogen
Recombinant fragment (around aa 32-155) of human FOLR2 protein
Alternate Names
Folate receptor beta, BETA-HFR|FBP|FBP/PL-1|FOLR1|FR-BETA|FR-P3|FRbeta

Database Links

Entrez Gene ID
2350
SwissProt
P14207

Additional Information

Clone
FOLR2/13393
Chromosome Location
11q13.4
Mol. Weight of Antigen
29.28kDa
Purification
Protein A

Related Antibodies

View All FOLR2 Antibodies

Functions

  • Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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