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Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with Ep-CAM Mouse Monoclonal Antibody (SPM134).
Immunofluorescence Analysis of MeOH-fixed MCF-7 cells labeling Ep-CAM with Ep-CAM Mouse Monoclonal Antibody (SPM134) followed by Goat anti-Mouse IgG-CF488 (green). The nuclear counterstain is NucSpot (Red).
EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.
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