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CD8B (Cytotoxic / Suppressor T-Cell Marker) Antibody [CBB/1595]

In Stock
Catalog Number Formulation Size Price
926-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
926-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
926-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Bovine, Goat, Sheep
Research Areas
Immunology, Infectious Disease, PD-1 blockade immunotherapy
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
CD8B
Positive Control
HuT78 or hPBL. Tonsil.
Immunogen
Antibody was raised against bovine CD8b.
Alternate Names
T-cell surface glycoprotein CD8 beta chain, CD8 antigen 37kDa chain; CD8 antigen, beta chain; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta polypeptide 1; CD8B; LEU2; LYT3; OX 8 membrane antigen; p37; T cell surface glycoprotein CD8 beta chain

Database Links

Entrez Gene ID
926
SwissProt
P10966

Additional Information

Clone
CBB/1595
Chromosome Location
2p11.2
Mol. Weight of Antigen
32kDa

Related Antibodies

View All CD8B Antibodies

Functions

  • Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells.

Key References

  • Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989
  • Parnes JR. Semin Immunol 1994, 6:221-229.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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