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CD74 (B-Cell Marker) (Transcription Regulator) Antibody [CLIP/7945]

Additional information

Catalog Number: 972-MSM19
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

download data sheet
In Stock
Catalog Number Formulation Size Price
972-MSM19-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
972-MSM19-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
972-MSM19-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD74 (B-Cell Marker) (Transcription Regulator) Antibody

Formalin-fixed, paraffin-embedded human tonsil stained with CD74 Mouse Monoclonal Antibody (CLIP/7945) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control.

CD74 (B-Cell Marker) (Transcription Regulator) Antibody - Image 2

SDS-PAGE Analysis of Purified CD74 Mouse Monoclonal Antibody (CLIP/7945). Confirmation of Purity and Integrity of Antibody.

CD74 Antibody in Western Blot (WB)

CD74 Antibody in Western Blot (WB)

Western Blot Analysis of Raji lysate using CD74 Mouse Monoclonal Antibody (CLIP/7945).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
CLIP/7945
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell surface. Paranuclear globular.
Gene Name
CD74
Positive Control
Raji, Human tonsil or lymph node.
Immunogen
Recombinant fragment of human CD74 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
  • Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.
  • Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215).
Key References
  • Epstein AL et. al. J of Immunology 133: 1028-1036, 1984.
  • Marder RJ et. al. Lab Invest 52: 497-504, 1985.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
972
SwissProt
P04233
Chromosome Location
5q33.1
Mol. Weight of Antigen
33-41kDa
Alternate Names
HLA class II histocompatibility antigen gamma chain | Class-II-associated invariant chain peptide, HLA-DR antigens-associated invariant chain, Ia antigen-associated invariant chain, CLIP, DHLAG, Gamma chain of class II antigens, HLA class II histocompatibility antigen gamma chain, HLA-DR antigens-associated invariant chain, HLADR-gamma (HLADG), Ia antigen-associated invariant chain, la-gamma, Major histocompatibility complex class II invariant chain, MHC HLA-DR gamma chain

Summary

It recognizes a protein of ~35kDa, identified as CD74 (Workshop IV). CD74 is a type II transmembrane protein which binds to the peptide binding groove of newly synthesized MHC class II alpha/beta heterodimers and prevents their premature association with endogenous polypeptides. CD74 is expressed primarily by antigen presenting cells, such as B-lymphocytes (from before the pre-B cell stage to before the plasma cell stage), macrophages, and monocytes, and many epithelial cells. Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas, but rarely T-cell lymphomas. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma (-) from malignant fibrous histiocytoma (+).

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