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CD5 (Mantle Cell Lymphoma Marker) Antibody [SPM546]

Additional information

Catalog Number: 921-MSM1X
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
921-MSM1X-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
921-MSM1X-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
921-MSM1X-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD5 (Mantle Cell Lymphoma Marker) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with CD5 Monoclonal Antibody (SPM546)

CD5 Antibody in SDS-PAGE

CD5 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified T-cell surface glycoprotein CD5 Mouse Monoclonal Antibody (SPM546). Confirmation of Purity and Integrity of Antibody.

CD5 Antibody in SDS-PAGE

CD5 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified T-cell surface glycoprotein CD5 Recombinant Mouse Monoclonal Antibody (SPM546). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • IF
  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry
Species Reactivity
Human
Clone
SPM546
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CD5
Positive Control
293T, Ramos or MOLT-4 cells. Tonsil.
Immunogen
Human CD5 recombinant protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • May act as a receptor in regulating T-cell proliferation.
Key References
  • Ferry JA et. al. American Journal of Clinical Pathology, 1996, 105(1):31-7.
  • Gagneten D et. al. Diagnostic Cytopathology, 1996, 14(1):32-7.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
921
SwissProt
P06127
Chromosome Location
11q12.2
Mol. Weight of Antigen
~67kDa
Alternate Names
T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

Summary

Recognizes a 67kDa transmembrane protein, which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Anti-CD5 detection is diagnostic in CLL/SLL within a panel of other B-cell markers, especially one that includes anti-CD23. Anti-CD5 is also very useful in differentiating among mature small lymphoid cell malignancies. In addition, anti-CD5 can be used in distinguishing thymic carcinoma (+) from thymoma (-). Anti-CD5 does not react with granulocytes or monocytes.

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