Formalin-fixed, paraffin-embedded human tonsil stained with CD14 Rabbit Recombinant Monoclonal Antibody (LPSR/4180R).
Formalin-fixed, paraffin-embedded human tonsil stained with CD14 Rabbit Recombinant Monoclonal Antibody (LPSR/4180R).
CD14 is receptor for endotoxin and apoptotic cells. It is expressed by monocytes/histiocytes, Langerhans' cells, follicular dendritic reticulum cells, neutrophils (weakly), and endothelial cells of the liver sinusoids.CD14 is detected in myeloid leukemias with monoblastic/monocytic differentiation, and in histiocytic neoplasms like histiocytic lymphoma, Langerhans' cell histiocytosis and giant cell tumor. In cultures, a subpopulation of Kaposi sarcoma cells express CD14. In differential diagnosis, CD14 is more specific than CD68 in the identification of monocytes/histiocytes and associated neoplasias.
