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CCL18 / C-C motif chemokine ligand 18 Antibody [CCL18/3744]

Additional information

Catalog Number: 6362-MSM4
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
6362-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6362-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6362-MSM4-P1ABX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CCL18 / C-C motif chemokine ligand 18 Antibody

SDS-PAGE Analysis of Purified CCL18 Mouse Monoclonal Antibody (CCL18/3744). Confirmation of Purity and Integrity of Antibody.

CCL18 / C-C motif chemokine ligand 18 Antibody - Image 2

Formalin-fixed, paraffin-embedded human adrenal gland stained with CCL18 Mouse Monoclonal Antibody (CCL18/3744). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
CCL18/3744
Isotype
IgG
Cellular Localization
Secreted
Gene Name
CCL18
Positive Control
Human lung, lymph node, placenta or tonsil.
Immunogen
Recombinant fragment (around aa1-89) of human CCL18 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.
Key References
  • Pacini, G., et al. 2018. The fibrogenic chemokine CCL18 is associated with disease severity in Erdheim-Chester disease. Oncoimmunology 7: e1440929.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6362
SwissProt
P55774
Chromosome Location
17q12
Mol. Weight of Antigen
7kDa
Alternate Names
C-C motif chemokine 18, Alternative macrophage activation-associated CC chemokine 1 (AMAC-1), CC chemokine PARC Dendritic cell chemokine 1 (DC-CK1); Macrophage inflammatory protein 4 (MIP-4); Pulmonary and activation-regulated chemokine; Small-inducible cytokine A18

Summary

Chemokines are members of a superfamily of small inducible, secreted, proinflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In C-C (or b) subfamily, the first two cysteines are adjacent. C-C chemokines are chemoattractants and activators for monocytes and T cells. C-C subfamily members include macrophage inflammatory protein (MIP)-1a, MIP-1b, MIP-2, MIP-3a, MIP-3b, MIP-4, HCC-1, MIP-5 (or HCC-2), RANTES, MCP-1/2/3 (and the murine homologs JE and MARC), I-309, murine C10 and TCA3. MIP-4 is constituitively expressed in several normal tissues and is highly expressed in plasma.

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