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Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Antibody [h-CALD]

Additional information

Catalog Number: 800-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
800-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
800-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
800-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Antibody

Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with Caldesmon Mouse Monoclonal Antibody (h-CALD).

Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified Caldesmon Mouse Monoclonal Antibody (h-CALD). Confirmation of Integrity and Purity of Antibody.

Caldesmon, HMW (h-Caldesmon) (Smooth Muscle Marker) Antibody - Image 3

Western Blot Analysis of human Ovary tissue using Caldesmon Mouse Monoclonal Antibody (h-CALD).

CALD1 Antibody in SDS-PAGE

CALD1 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Caldesmon Recombinant Mouse Monoclonal Antibody (h-CALD). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
h-CALD
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Cytoskeleton, Myofibril, Stress fiber
Gene Name
CALD1
Positive Control
Blood vessels in all tissues, smooth muscle or leiomyosarcoma., Uterus
Immunogen
Crude human uterus extract
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity).
Key References
  • Frid MG, et al. Phenotypic changes of human smooth muscle cells during development: Late expression of heavy caldesmon and calponin. Dev Biol 1992; 153:185
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
800
SwissProt
Q05682
Chromosome Location
7q33
Mol. Weight of Antigen
150kDa
Alternate Names
Caldesmon, CAD; CALD1; Caldesmon 1 Isoform 1; Caldesmon 1 Isoform 2; Caldesmon 1 Isoform 3; Caldesmon 1 Isoform 4; Caldesmon 1 Isoform 5; CDM; HCAD; LCAD; NAG22

Summary

Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120'150kDa) is predominantly expressed in smooth muscle whereas l-caldesmon (70'80kDa) is found in non- muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.

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