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BCL2-like 2 (BCL2L2) / BCL-W Antibody [PCRP-BCL2L2-1A4]

In Stock
Catalog Number Formulation Size Price
599-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
599-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
599-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Mitochondrion membrane
Gene Name
Positive Control
HEK293, HePG2, MCF-7 or U87 cells., PC-3
Immunogen
Recombinant human full-length BCL2L2 protein
Alternate Names
Bcl-2-like protein 2, Apoptosis regulator Bcl-W, BCL-W, BCL2-L-2, BCLW, KIAA0271, PPP1R51

Database Links

Entrez Gene ID
599
SwissProt

Additional Information

Clone
PCRP-BCL2L2-1A4
Chromosome Location
14q11.2-q12
Mol. Weight of Antigen
22-30kDa

Functions

  • Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Key References

  • Blackshaw S, et al. A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nature methods 15.5 (2018 May): 330-338.
  • O Reilly, L. A. et al. Tissue expression and subcellular localization of the pro-survival molecule Bcl-w.Cell Death Differ.8, 486 494 (2001).

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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