SDS-PAGE Analysis Purified Aromatase / CYP450 Mouse Monoclonal Antibody (CYP19A1/4257). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis Purified Aromatase / CYP450 Mouse Monoclonal Antibody (CYP19A1/4257). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human placenta stained with Aromatase / CYP450 Mouse Monoclonal Antibody (CYP19A1/4257).

Formalin-fixed, paraffin-embedded human placenta stained with Aromatase / CYP450 Mouse Monoclonal Antibody (CYP19A1/4257).

Printable Datasheet

Aromatase / Cytochrome P450 (CYP19A1) [CYP19A1/4257]

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Summary

CYP450 Aromatase is part of the CYP19A1 family involved in the aromatization of androgens to estrogens, a highly conserved mechanism amongst mammals. Clone CYP19A1/4257 recognizes a conserved epitope on the CYP450 aromatase, allowing for detection of aromatase levels using various analysis methods.

Product Properties & Targets

Host
Mouse
Applications
ELISA, Immunohistochemistry, Western Blot
Species Reactivity
Human
Isotype
IgG2a
Cellular Localization
Secreted
Gene Name
MSTN
Positive Control
Human normal placenta.
Immunogen
Synthetic peptide corresponding to aa376-390 of human aromatase (KALEDDVIGYPVKK)
Alternate Names
Growth/differentiation factor 8, Myostatin, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1, Estrogen synthase, CYP19A1, ARO1, CYAR, CYP19

Database Links

Entrez Gene ID
1588
Unigene
41565
SwissProt
O14793

Additional Information

Clone
CYP19A1/4257
Human Gene Symbol
CYP19A1
Chromosome Location
2q32.2
Mol. Weight of Antigen
55kDa

Functions

  • Acts specifically as a negative regulator of skeletal muscle growth.

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA)
  • Western Blot (1-2ug/ml)
  • ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Turner, KJ, et al. (2002) Development and Validation of a New Monoclonal Antibody to Mammalian Aromatase. Journal of Endocrinology.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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