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Recombinant ACTH (Adrenocorticotrophic Hormone) (Pituitary Marker) Antibody [CLIP/2040R]

In Stock
Catalog Number Formulation Size Price
5443-RBM10-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5443-RBM10-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5443-RBM10-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. '

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Secreted
Gene Name
Positive Control
Normal pituitary gland or pituitary tumor.
Immunogen
Synthetic peptide corresponding to (aa 162-176) of human ACTH (NGAEDESAEAFPLEF)
Alternate Names
Pro-opiomelanocortin, Corticotropin-lipotropin, Adrenocorticotropin; alpha or beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin; beta-Endorphin; beta or gamma Lipotropin (LPH); CLIP; Met Enkephalin; POC; POMC

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CLIP/2040R
Chromosome Location
2p23.3
Mol. Weight of Antigen
ACTH is ~5kDa|and the POMC precursor is ~30kDa. The molecular weight of POMC depends upon isoform variation and post-translational modifications.

Functions

  • Stimulates the adrenal glands to release cortisol.
  • Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.
  • Increases the pigmentation of skin by increasing melanin production in melanocytes.
  • Endogenous orexigenic opiate.
  • Endogenous opiate.

Key References

  • Hsu DW et. al. American Journal of Pathology, 1991, 138(4):897-909.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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