Cytokeratin 10 (CK10) is a protein encoded by the KRT10 gene on chromosome 17q21.2 in humans. It typically consists of around 584 amino acids and has a molecular weight of approximately 56 kDa. Post-translational modifications of CK10 include phosphorylation, glycosylation, and the formation of disulfide bonds, which contribute to its structural stability and functional diversity. CK10 is primarily an intracellular protein, forming intermediate filaments that provide structural support and integrity to epithelial cells. CK10 is a major component of the cytoskeleton in the suprabasal layers of the epidermis, contributing to the skin’s mechanical strength and barrier function. Additionally, CK10 plays a role in keratinocyte differentiation and epithelial homeostasis.
Altered CK10 expression has been associated with several skin disorders, including ichthyosis, epidermolytic hyperkeratosis, and palmoplantar keratoderma. These conditions are characterized by abnormal keratinization of the skin, leading to thickened, scaly, or blistered skin. CK10 expression has also been utilized as a marker of specific cell types and disease states in dermatopathology. Its expression pattern can provide valuable diagnostic and prognostic information in skin disorders, aiding in accurate diagnosis and treatment planning. Additionally, CK10 expression may be used to differentiate between different types of skin tumors and predict patient outcomes.
NeoBiotechnologies offers a variety of antibodies against CK10 that have been validated for flow cytometry, immunofluorescence, immunohistochemistry, and Western blotting, as well as a HuProt-validated option. Additionally, we hold exclusive rights to CK10 antibodies available for licensing or collaboration [https://www.neobiotechnologies.com/shop/?s=KRT10].
Synonyms
Keratin, type I cytoskeletal 10, Cytokeratin-10, Keratin-10, BCIE, BIE, EHK, Keratin Type I Cytoskeletal 10, KRT10
Research Areas
Developmental Biology
