PARTNERSHIP OPPORTUNITIES
Cytokeratin 10 (CK10) is a protein encoded by the KRT10 gene on chromosome 17q21.2 in humans. It typically consists of around 584 amino acids and has a molecular weight of approximately 56 kDa. Post-translational modifications of CK10 include phosphorylation, glycosylation, and the formation of disulfide bonds, which contribute to its structural stability and functional diversity. CK10 is primarily an intracellular protein, forming intermediate filaments that provide structural support and integrity to epithelial cells. CK10 is a major component of the cytoskeleton in the suprabasal layers of the epidermis, contributing to the skin’s mechanical strength and barrier function. Additionally, CK10 plays a role in keratinocyte differentiation and epithelial homeostasis.
Altered CK10 expression has been associated with several skin disorders, including ichthyosis, epidermolytic hyperkeratosis, and palmoplantar keratoderma. These conditions are characterized by abnormal keratinization of the skin, leading to thickened, scaly, or blistered skin. CK10 expression has also been utilized as a marker of specific cell types and disease states in dermatopathology. Its expression pattern can provide valuable diagnostic and prognostic information in skin disorders, aiding in accurate diagnosis and treatment planning. Additionally, CK10 expression may be used to differentiate between different types of skin tumors and predict patient outcomes.
NeoBiotechnologies offers a variety of antibodies against CK10 that have been validated for flow cytometry, immunofluorescence, immunohistochemistry, and Western blotting, as well as a HuProt-validated option. Additionally, we hold exclusive rights to CK10 antibodies available for licensing or collaboration [https://www.neobiotechnologies.com/shop/?s=KRT10].
Keratin, type I cytoskeletal 10, BCIE|BIE|CK10|EHK|EHK2|EHK2A|EHK2B|IHL|K10|KPP
Apoptosis, Autophagy, Breast Cancer, Cancer, Cardiovascular, Cell Biology, Cellular Markers and Tags, Developmental Biology, Endocrine, Epigenetics, Gastrointestinal Tract, Hypoxia, Immuno Oncology, Immunology, Kidney, Lymphatic, Metabolism, Microbiology, Muscle, Neuroscience, Pancreatic Cancer, Prostate Cancer, Skin, Stem Cell, AKT Signaling, Angiogenesis, Articular Cartilage Extracellular Matrix, B Cell Markers, Basal Cell Marker, BBB VCAM-1 Signaling, Bladder Cancer, Cardiac Stem Cells, Colon Cancer, Colorectal Cancer, Complement System, CTLA-4 blockade immunotherapy, Cytokine Signaling, Defective Intrinsic Apoptosis, Dendritic Cell Marker, Digestion, Endothelial Cell Marker, Hematopoietic Stem Cells, Immune checkpoint, Infectious Disease, Lipid Metabolism, Lung Cancer, MAPK Signaling, Mast Cell Marker, Melanoma, Mesenchymal Stem Cell Differentiation, Mitochondria Marker, Neural Stem Cells, Neuroinflammation, Nuclear Marker, Oncology, Ovarian Cancer, PD-1 blockade immunotherapy, Signal Transduction, Stem Cell Differentiation, Transcription Factors
Showing all 20 results
Showing all 20 results
