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ZNF202 Antibody [PCRP-ZNF202-1C4]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
7753-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7753-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7753-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells

Summary

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF202 (zinc finger protein 202), also known as ZKSCAN10, is a 648 amino acid protein that contains eight C2H2-type zinc fingers, one KRAB domain and one SCAN box domain. Localized to the nucleus and expressed at high levels in the testis, ZNF202 belongs to the Kruppel C2H2-type zincfinger protein family and functions as a transcriptional repressor of genes that are involved in lipid metabolism. ZNF202 regulates the expression of several classes of proteins, including lipoprotein particles, transporters involved in lipid homeostasis, enzymes involved in lipid processing and a wide variety of proteins that are associated with energy metabolism. Defects in the gene encoding ZNF202 are associated with high cholesterol and may be involved in the pathogenesis of lung, ovarian and breast cancer. Two isoforms of ZNF202, designated a and b, exist due to alternative splicing events

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2a /
Cellular Localization
Nucleus.
Gene Name
Positive Control
HeLa or MCF-7 cells.
Immunogen
Recombinant fragment (around 37-132) of human ZNF202 protein
Alternate Names
Zinc finger protein 202, Zinc finger protein with KRAB and SCAN domains 10, ZKSCAN10, ZSCAN42

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-ZNF202-1C4
Chromosome Location
11q24.1
Mol. Weight of Antigen
74.72kDa

Functions

  • Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipoprotein particles (apolipoproteins AIV, CIII, and E), enzymes involved in lipid processing (lipoprotein lipase, lecithin cholesteryl ester transferase), transporters involved in lipid homeostasis (ABCA1, ABCG1), and several genes involved in processes related to energy metabolism and vascular disease.

Key References

  • Blackshaw S. Nature methods15.5 (2018 May): 330-338.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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