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Recombinant TRPS1 (Transcriptional repressor GATA binding 1) Antibody [TRPS1/8008R]

In Stock
Catalog Number Formulation Size Price
7227-RBM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
7227-RBM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
7227-RBM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
TRPS1 Antibody in Immunohistochemistry (IHC (P))

TRPS1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human mammary cancer stained with TRPS1 Recombinant Rabbit Monoclonal Antibody (TRPS1/8008R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

TRPS1 Antibody in Immunohistochemistry (IHC (P))

TRPS1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human breast cancer stained with TRPS1 Recombinant Rabbit Monoclonal Antibody (TRPS1/8008R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

TRPS1 Antibody in Immunohistochemistry (IHC (P))

TRPS1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human uterus stained with TRPS1 Recombinant Rabbit Monoclonal Antibody (TRPS1/8008R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

TRPS1 Antibody in Immunohistochemistry (IHC (P))

TRPS1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human triple negative breast cancer (TNBC) stained with TRPS1 Recombinant Rabbit Monoclonal Antibody (TRPS1/8008R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

TRPS1 Antibody in Immunohistochemistry (IHC (P))

TRPS1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human breast cancer stained with TRPS1 Recombinant Rabbit Monoclonal Antibody (TRPS1/8008R). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

TRPS1 Antibody in SDS-PAGE

TRPS1 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Zinc finger transcription factor Trps1 Recombinant Rabbit Monoclonal Antibody (TRPS1/8008R). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Nuclear Marker
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Nucleus.
Gene Name
TRPS1
Positive Control
Human squamous epithelium, breast or breast cancer
Immunogen
Recombinant fragment (around aa900-1100) of human TRPS1 protein (exact sequence is proprietary)
Alternate Names
Zinc finger transcription factor Trps1, Tricho-rhino-phalangeal syndrome type I protein, Zinc finger protein GC79, GC79; LGCR; Transcriptional repressor GATA binding 1; Tricho-rhino-phalangeal syndrome type I protein; Trichorhinophalangeal syndrome I; Trichorhinophalangeal syndrome I homolog; TRPS 1; trpS1; TRPS1 gene; TRPS1_HUMAN; Zinc finger protein GC79; Zinc finger transcription factor TRPS 1 antibody

Database Links

Entrez Gene ID
7227
SwissProt
Q9UHF7

Additional Information

Clone
TRPS1/8008R
Chromosome Location
8q23.3
Mol. Weight of Antigen
142kDa

Related Antibodies

View All TRPS1 Antibodies

Functions

  • Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.

Key References

  • Ai, Di et al. TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. Modern pathology: an official journal of the United States and Canadian Academy of Pathology, Inc vol. 34,4 (2021): 710-719. doi:10.1038/s41379-020-00692-8

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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