Formalin-fixed, paraffin-embedded human tonsil stained with Topo IIa Recombinant Rabbit Monoclonal Antibody (TOP2A/6570R).
IHC analysis of formalin-fixed, paraffin-embedded human brain. Negative tissue control using TOP2A/6570R at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis Purified Topo IIa Recombinant Rabbit Monoclonal Antibody (TOP2A/6570R). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human lymph node stained with Topo IIa Recombinant Rabbit Monoclonal Antibody (TOP2A/6570R).
Western Blot Analysis of HeLa and Jurkat cell lysates using Topo IIa Recombinant Rabbit Monoclonal Antibody (TOP2A/6570R).
Formalin-fixed, paraffin-embedded human lymph node stained with Topo IIa Recombinant Rabbit Monoclonal Antibody (TOP2A/6570R).
The topoisomerase II-伪 isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-伪 is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-伪 is the predominant mechanism of resistance to several chemotherapeutic agents.
