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Recombinant Uroplakin 3B (UPK3B) (Marker of Mesothelial & Umbrella Cells) Antibody [UPK3B/8768R]

Additional information

Catalog Number: 105375355-RBM3
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
105375355-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
105375355-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
105375355-RBM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Uroplakin 3B (UPK3B) (Marker of Mesothelial & Umbrella Cells) Antibody

Formalin-fixed, paraffin-embedded human bladder stained with Uroplakin 3B Recombinant Rabbit Monoclonal Antibody (UPK3B/8768R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant Uroplakin 3B (UPK3B) (Marker of Mesothelial & Umbrella Cells) Antibody - Image 2

SDS-PAGE Analysis of Purified UPK3B Recombinant Rabbit Monoclonal Antibody (UPK3B/8768R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
UPK3B/8768R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
UPK3B
Positive Control
Human urinary bladder.
Immunogen
Recombinant fragment (around aa130-234) of the human Uroplakin 3B protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
105375355
SwissProt
Q9BT76
Chromosome Location
7q11.23
Mol. Weight of Antigen
33.88kDa
Alternate Names
Uroplakin-3b, P35|UP3B|UPIIIB

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. �

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