Recombinant Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody [rG3E6]

Summary

Tyrosinase-related protein-1 (TRP-1) is a member of a family of proteins which are involved in melanin biosynthesis. The catalytic function of TRP-1 has not been fully resolved but the enzyme appears to be important in the oxidation of 5,6-dihydroxyindole-2-carboxylic acid to form a high molecular weight pigmented biopolymer. In mammals, there are two basic types of melanin, the brown-black eumelanin and the reddish-yellow phaeomelanin. The concentrations of each are variable and are not related to skin type. In skin exposed to suberythemal doses of UVB, an increase in the number of melanocytes expressing TRP-1 and TRP-2 was observed with no increase noted in the number of tyrosinase-expressing melanocytes. In normal, untreated skin the number of melanocytes which immunohistochemically stain for either TRP-1, TRP-2 or tyrosinase appears to be similar irrespective of skin type. TRP-1 is also expressed in more than 50 per cent of choroidal melanocytes of the adult eye.