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Recombinant Synaptophysin (Neuroendocrine Marker) Antibody [rSYP/8807]

Additional information

Catalog Number: 6855-MSM10
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

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In Stock
Catalog Number Formulation Size Price
6855-MSM10-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6855-MSM10-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6855-MSM10-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Synaptophysin (Neuroendocrine Marker) Antibody

Formalin-fixed, paraffin-embedded human pancreas stained with Synaptophysin Recombinant Mouse Monoclonal Antibody (rSYP/8807). Inset: PBS instead of primary antibody; secondary only negative control.

Recombinant Synaptophysin (Neuroendocrine Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified Synaptophysin Recombinant Mouse Monoclonal Antibody (rSYP/8807). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rSYP/8807
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cytoplasmic vesicle, Secretory vesicle, Synapse, Synaptic vesicle membrane, Synaptosome
Gene Name
SYP
Positive Control
cerebellum or pheochromocytoma.|HeLa or Y79 cells. Human pancreas|HepG2
Immunogen
Recombinant fragment (around aa274-313) of the human Synaptophysin protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6855
SwissProt
P08247
Chromosome Location
Xp11.23
Mol. Weight of Antigen
33.84kDa
Alternate Names
Synaptophysin, MRX96|MRXSYP|XLID96

Summary

This recombinant mouse monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel.This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

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