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Recombinant Prolactin Receptor (hPRL Receptor) Antibody [rPRLR/742]

Additional information

Catalog Number: 5618-MSM5
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

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In Stock
Catalog Number Formulation Size Price
5618-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5618-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5618-MSM5-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Prolactin Receptor (hPRL Receptor) Antibody

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Prolactin Receptor Recombinant Mouse Monoclonal Antibody (rPRLR742).

Recombinant Prolactin Receptor (hPRL Receptor) Antibody - Image 2

Formalin-fixed, paraffin-embedded human breast carcinoma stained with Prolactin Receptor Recombinant Mouse Monoclonal Antibody (rPRLR742).

Recombinant Prolactin Receptor (hPRL Receptor) Antibody - Image 3

SDS-PAGE Analysis of Purified Prolactin Receptor Recombinant Mouse Monoclonal (rPRLR742). Confirmation of Integrity and Purity of Antibody.

Prolactin Receptor Antibody in Western Blot (WB)

Prolactin Receptor Antibody in Western Blot (WB)

Western blot analysis of Human Kidney tissue lysate using Prolactin Receptor Mouse Recombinant Monoclonal Antibody (rPRLR/742).

Prolactin Receptor Antibody in Western Blot (WB)

Prolactin Receptor Antibody in Western Blot (WB)

Western blot analysis of Kidney tissue lysates of different species using Prolactin Receptor Mouse Recombinant Monoclonal Antibody (rPRLR/742).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rPRLR/742
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Membrane, Secreted
Gene Name
PRLR
Positive Control
Testicular Carcinoma. Kidney.
Immunogen
Recombinant full-length human PRLR protein
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5618
SwissProt
P16471
Chromosome Location
5p13.2
Mol. Weight of Antigen
69.5kDa
Alternate Names
Prolactin receptor, HPRL|MFAB|RI-PRLR|hPRLrI

Summary

It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.

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