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Recombinant Peripherin / PRPH (Marker of Peripheral Neurons) Antibody [rPJM50]

In Stock
Catalog Number Formulation Size Price
6439-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
6439-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
6439-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Peripherin Antibody in Immunohistochemistry (IHC (P))

Peripherin Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human adrenal gland stained with Peripherin Recombinant Mouse Monoclonal Antibody (rPJM50). Inset: PBS instead of primary antibody; secondary only negative control.

Peripherin Antibody in SDS-PAGE

Peripherin Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Peripherin Recombinant Mouse Monoclonal Antibody (rPJM50). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Peripherin is a 57 kD type III intermediate filament that is a specific marker for peripheral neurons, including enteric ganglion cells. Peripherin is expressed in the developing peripheral nervous system and is highly enriched in neuronal derivatives of the neural crest. Peripherin offers an advantage over other neural markers, such as S100 and NSE in that it does not stain chromaffin cell types.

Product Properties & Targets

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Neuroscience, Neuroinflammation
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Axon, Cell projection, Cytoplasm
Gene Name
PRPH
Positive Control
Human small bowel, peripheral nerves or ganglion cells. Kelly cell line.
Immunogen
Prokaryotic recombinant protein corresponding to the full-length peripherin molecule
Alternate Names
Peripherin, Neurofilament 4, PRPH, NEF4, PRPH1

Database Links

Entrez Gene ID
5630
SwissProt
P41219

Additional Information

Clone
rPJM50
Chromosome Location
12q13.12
Mol. Weight of Antigen
57kDa

Related Antibodies

View All PRPH Antibodies

Functions

  • Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (PubMed:15322088, PubMed:15446584). Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea.

Key References

  • Szabolcs M J, Visser J, Shelanski M L, et al. Pediatric Pathology & Laboratory Medicine. 16: 51–70 (1996).
  • Foley J, Witte D, Chiu F-C, et al. Laboratory Investigation. 71 (2): 193–199 (1994).
  • Kajiwara K, Berson E L and Dryja T P. Science. 264: 1604–1608 (1994).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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