Trial Size Available
Carrier-Free Available
SDS-PAGE Analysis of Purified Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human prostate stained with Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Inset: PBS instead of primary antibody; secondary only negative control.
Formalin-fixed, paraffin-embedded human lung stained with Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522). Inset: PBS instead of primary antibody; secondary only negative control.
Western blot analysis of Human Kidney tissue lysate using Periostin Recombinant Mouse Monoclonal Antibody (rPOSTN/8522).
| Document Name | |
|---|---|
| Datasheet | Download Here |
| Material Safety Data Sheet | Download Here |
| Applications | Tested Dilutions | Protocol | Note |
|---|---|---|---|
| Immunohistochemistry (IHC) | 1-2ug/ml | IHC Protocol | 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes |
| Western Blot (WB) | 2-4ug/ml | Western Blot Protocol |
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Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for Î �VÎ �3 and Î �VÎ �5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor Î � 1 (TGF Î � 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
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