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Recombinant MCM7 (Proliferation Marker) Antibody [MCM7/2832R]

Additional information

Catalog Number: 4176-RBM7
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4176-RBM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4176-RBM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4176-RBM7-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant MCM7 (Proliferation Marker) Antibody

Formalin-fixed, paraffin-embedded human Lymph Node stained with MCM7 Rabbit Recombinant Monoclonal Antibody (MCM7/2832R).

Recombinant MCM7 (Proliferation Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Tonsil stained with MCM7 Rabbit Recombinant Monoclonal Antibody (MCM7/2832R).

MCM7 Antibody in Western Blot (WB)

MCM7 Antibody in Western Blot (WB)

Western Blot Analysis of A549 and HEK293 lysates using MCM7 Rabbit Recombinant Monoclonal Antibody (MCM7/2832R).

MCM7 Antibody in SDS-PAGE

MCM7 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified DNA replication licensing factor MCM7 Recombinant Rabbit Monoclonal Antibody (MCM7/2832R). Confirmation of Purity and Integrity of Antibody.

MCM7 Antibody Validation in Western Blot on Knockdown(KD) cells.

MCM7 Antibody Validation in Western Blot on Knockdown(KD) cells.

Western Blot validation of anti-MCM7 antibody. MCM7 protein expression was compared in wild-type (WT) and MCM7 shRNA Knockdown (KD) HT-1080 cells (30ug of total protein). Loading control is shown below.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
MCM7/2832R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Chromosome, Nucleus
Gene Name
MCM7
Positive Control
A-431, A549, HEK-293, HeP2, MCF-7, Raji or Ramos cells. Tonsil., SKBR3
Immunogen
Recombinant fragment (around aa195-319) of the human MCM7 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4176
SwissProt
P33993
Chromosome Location
7q22.1
Mol. Weight of Antigen
81.31kDa
Alternate Names
DNA replication licensing factor MCM7, CDC47|MCM2|P1.1-MCM3|P1CDC47|P85MCM|PNAS146|PPP1R104

Summary

MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that is essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB.

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