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Formalin-fixed, paraffin-embedded human CMV-infected tissue stained with Cytomegalovirus (CMV) pp65 Recombinant Mouse Monoclonal Antibody (r6). Inset: PBS instead of primary antibody; secondary only negative control.
SDS-PAGE Analysis of Purified CMV-p65 Recombinant Mouse Monoclonal Antibody (r6). Confirmation of Purity and Integrity of Antibody.
Cytomegalovirus (CMV) is a member of the Herpes virus family. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid which is embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope that is decorated with virus-specific glycoprotein spikes. The vial genes are co- ordinately expressed in groups at various times after infection. Early viral proteins are expressed in the nucleus of infected cells within 3 to 24 hours of infection prior to the commencement of viral DNA replication. This is followed by expression of the early intermediate genes, which encode enzymes required for viral DNA replication. After 48 to 72 hours, a number of late viralantigens may be demonstrated in the nuclei and cytoplasm of infected cells. pp65 is a 65 kDa phosphorylated glycoprotein and is the most abundant of the late antigens.
