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Recombinant Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker) Antibody [rAKR1B1/7296]

Additional information

Catalog Number: 231-MSM6
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
231-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
231-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
231-MSM6-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Aldo-keto Reductase Family 1 Member B1 Antibody in Immunohistochemistry (IHC (P)).

Aldo-keto Reductase Family 1 Member B1 Antibody in Immunohistochemistry (IHC (P)).

Formalin-fixed, paraffin-embedded human adrenal gland stained with Aldose Reductase Recombinant Mouse Monoclonal Antibody (rAKR1B1/7296). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.

Aldo-keto Reductase Family 1 Member B1 Antibody in SDS-PAGE.

Aldo-keto Reductase Family 1 Member B1 Antibody in SDS-PAGE.

SDS-PAGE Analysis of Purified Aldose Reductase Recombinant Mouse Monoclonal Antibody (rAKR1B1/7296). Confirmation of Purity and Integrity of Antibody.

AKR1B1 Antibody in Western Blot (WB)

AKR1B1 Antibody in Western Blot (WB)

Western blot analysis of HEK293T lysate using AKR1B1 Recombinant Mouse Monoclonal Antibody (rAKR1B1/7296).

AKR1B1 Antibody in Western Blot (WB)

AKR1B1 Antibody in Western Blot (WB)

Western blot analysis of Human Kidney and HEK293T lysates using AKR1B1 Recombinant Mouse Monoclonal Antibody (rAKR1B1/7296).

AKR1B1 Antibody in Western Blot (WB)

AKR1B1 Antibody in Western Blot (WB)

Western blot analysis of Kidney tissue lysates of different species using AKR1B1 Recombinant Mouse Monoclonal Antibody (rAKR1B1/7296).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rAKR1B1/7296
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm
Gene Name
AKR1B1
Positive Control
HEK293T cells. Kidney, Lung, Spleen.
Immunogen
Recombinant full-length human Aldo-keto Reductase Family 1 Member B1 protein
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
231
SwissProt
P15121
Chromosome Location
7q33
Mol. Weight of Antigen
35.85kDa
Alternate Names
Aldo-keto reductase family 1 member B1, ADR|ALDR1|ALR2|AR

Summary

AKR1B1, also designated as aldose reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis.

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