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Recombinant 14-3-3E / Tryptophan 5-Monooxygenase Antibody [YWHAE/8636R]

Additional information

Catalog Number: 7531-RBM3
Gene:

Host:

Reactivity:

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In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
7531-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7531-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7531-RBM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant 14-3-3E / Tryptophan 5-Monooxygenase Antibody

Formalin-fixed, paraffin-embedded human prostate carcinoma stained with 14-3-3E Recombinant Rabbit Monoclonal Antibody (YWHAE/8636R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant 14-3-3E / Tryptophan 5-Monooxygenase Antibody - Image 2

SDS-PAGE Analysis of Purified 14-3-3E Recombinant Rabbit Monoclonal Antibody (YWHAE/8636R). Confirmation of Purity and Integrity of Antibody.

YWHAE Antibody in Western Blot (WB)

YWHAE Antibody in Western Blot (WB)

Western blot analysis of 293T, PC-3 and A431 lysates using YWHAE Recombinant Rabbit Monoclonal Antibody (YWHAE/8636R).

YWHAE Antibody in Western Blot (WB)

YWHAE Antibody in Western Blot (WB)

Western blot analysis of Human Brain, Mouse Brain, Rat Brain, Hamster Brain, Guinea pig Brain, Human Lungs, Mouse Lungs, Rat Lungs, Hamster Lungs and Guinea pig Lungs tissue lysates using YWHAE Recombinant Rabbit Monoclonal Antibody (YWHAE/8636R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Guinea Pig, Hamster, Human, Mouse, Rat
Clone
YWHAE/8636R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Melanosome, Nucleus
Gene Name
YWHAE
Positive Control
HEK-293 or A-431 cell lines. PC-3, Human brain|prostate or placenta. Human Brain, Mouse Brain, Rat Brain, Hamster Brain, Guinea pig Brain, Human Lungs, Mouse Lungs, Rat Lungs, Hamster Lungs or Guinea pig Lungs
Immunogen
Recombinant full-length human Tyrosine 3-monooxygenase or tryptophan 5-monooxygenase activation protein, epsilon polypeptide (14-3-3 epsilon) protein
Expression System
HEK293
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
7531
SwissProt
P62258
Chromosome Location
17p13.3
Mol. Weight of Antigen
29.17kDa
Alternate Names
14-3-3 protein epsilon, 14-3-3E|HEL2|KCIP-1|MDCR|MDS

Summary

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. The YWHAE gene which encodes 14-3-3E has also been identified as a possible susceptibility gene for schizophrenia.

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