PRKRA Antibody [PCRP-PRKRA-3A4]

Additional information

Catalog Number: 8575-MSM1
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
8575-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8575-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8575-MSM1-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • Flow
  • IF

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Host
Mouse
Species Reactivity
Clone
PCRP-PRKRA-3A4
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Cytoplasm, Perinuclear region
Gene Name
Immunogen
Recombinant human PRKRA protein
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
2q31.2
Mol. Weight of Antigen
34.4kDa
Alternate Names
Interferon-inducible double-stranded RNA-dependent protein kinase activator A, DYT16|HSD14|PACT|RAX

Summary

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at ‘Lys-386’ at ‘Ser-392’ respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

Worry-Free Guarantee

Should a NeoBiotechnologies antibody not meet the experimental expectations outlined on our website or datasheet, please contact our Technical Support. We unconditionally guarantee our product.

Need Technical Help?

Our team of scientists are ready to help you with expert recommendations or technical assistance related to applications or product use.