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Plakophilin-1 (PKP1) Antibody [10B2]

Additional information

Catalog Number: 5317-MSM1
Reactivity:

,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5317-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5317-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5317-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Plakophilin-1 (PKP1) Antibody

Western Blot of U87, HeLa and A431 cell lysates using Plakophilin-1 Mouse Monoclonal Antibody (10B2)

Plakophilin-1 (PKP1) Antibody - Image 2

SDS-PAGE Analysis of Purified CD56 Monoclonal Antibody (NCAM1/784). Confirmation of Integrity and Purity of Antibody

  • Flow
  • IF
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Western Blot
Species Reactivity
Human, Mouse
Clone
10B2
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell junction, Desmosome, Nucleus
Gene Name
PKP1
Positive Control
HeLa and A431 cells., U87
Immunogen
N-terminus of human Plakophilin-1 protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis.
Key References
  • Hadiji-Abbes, N. et al. 2014. Negative control glucose dependent mediated by the PreS2 region on the translation efficiency of the reporter Sh-bleomycin gene in Saccharomyces cerevisiae. FEMS Yeast Res. 14: 357-63.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5317
SwissProt
Q13835
Chromosome Location
1q32
Mol. Weight of Antigen
75kDa
Alternate Names
Plakophilin-1, Band 6 protein, B6P; Band 6 protein; PKP1; Plakophilin-1 (ectodermal dysplasia/skin fragility syndrome)

Summary

Recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.

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