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MRP1 / ABCC1 (Multidrug Resistance Related Protein 1) Antibody [MRP1/1343]

In Stock
Catalog Number Formulation Size Price
4363-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4363-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4363-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified MRP1/ABCC1 Monoclonal Antibody (MRP1/1343). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis of Purified MRP1/ABCC1 Monoclonal Antibody (MRP1/1343). Confirmation of Integrity and Purity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Flow Cytometry, Western Blot
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cell membrane
Gene Name
ABCC1
Positive Control
A549 cells. Colon, Endometrium, Ovary. Testis or Tonsil.
Immunogen
Recombinant full-length human ABCC1 protein
Alternate Names
Multidrug resistance-associated protein 1, ATP-binding cassette sub-family C member 1, Glutathione-S-conjugate-translocating ATPase ABCC1, Leukotriene C(4) transporter, ABC29; ABCC1; ATP binding cassette sub family C (CFTR/MRP) member 1; ATP-binding cassette sub-family C member 1; GSX; Leukotriene C(4) transporter; LTC4 transporter; Multidrug resistance-associated protein 1 (MRP1)

Database Links

Entrez Gene ID
4363
SwissProt
P33527

Additional Information

Clone
MRP1/1343
Chromosome Location
16p13.11
Mol. Weight of Antigen
190kDa

Related Antibodies

View All ABCC1 Antibodies

Functions

  • Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).

Key References

  • Faneyte IF, Kristel PM, van de Vijver MJ. Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer. Anticancer Res. 2004;24(5A):2931-9.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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