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Milk Fat Globule (Breast Epithelial Marker) Antibody [EDM45]

Additional information

Catalog Number: 4240-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4240-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4240-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4240-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Milk Fat Globule (Breast Epithelial Marker) Antibody

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Milk Fat Globule Monoclonal Antibody (EDM45)

Milk Fat Globule (Breast Epithelial Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with Milk Fat Globule Monoclonal Antibody (EDM45)

Milk Fat Globule (Breast Epithelial Marker) Antibody - Image 3

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Milk Fat Globule Monoclonal Antibody (EDM45)

Milk Fat Globule (Breast Epithelial Marker) Antibody - Image 4

Formalin-fixed, paraffin-embedded human Pancreas stained with Milk Fat Globule Monoclonal Antibody (EDM45)

  • Flow
  • IF
  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry
Species Reactivity
Human
Clone
EDM45
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Acrosome membrane, Cytoplasmic vesicle, Membrane, Secreted, Secretory vesicle
Gene Name
MFGE8
Positive Control
Normal breast or breast carcinoma.
Immunogen
Delipidated human milk fat globule membrane preparation
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
  • Main constituent of aortic medial amyloid.
Key References
  • Ceriani RL et al. Surface differentiation antigens of human mammary epithelial cells carried on the human milk fat globule. Proc Natl Acad Sci USA 1977, 74(2):582-6
  • Larocca D et al. A Mr 46,000 human milk fat globule protein that is highly expressed in human breast tumors contains factor VIII-like domains. Cancer Res 1991, 51: 4994-4998
  • Corcoran D and Walker RA. Ultrastructural localization of milk fat globule membrane antigens in human breast carcinomas. J Pathol 1990,161(2):161-6
  • Sterns EE et al. Prognostic significance of the immunohistochemical reaction to human milk fat globule antibodies in node-negative and node-positive breast cancer. Breast Cancer Res Treat 1992, 21(3):193-9
  • Baildam AD et al. The expression of milk fat globule antigens within human mammary tumours: relationship to steroid hormone receptors and response to endocrine treatment. Eur J Cancer Clin Oncol 1989, 25(3):459-67
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4240
SwissProt
Q08431
Chromosome Location
15q25
Mol. Weight of Antigen
45kDa
Alternate Names
Lactadherin, Breast epithelial antigen BA46, HMFG, MFGM, Milk fat globule-EGF factor 8, SED1, Breast epithelial antigen BA46; EDIL1; HMFG; Lactadherin; Lactadherin precursor; Medin; MFGE8; MFGM; Milk fat globule-EGF factor 8 (MFG-E8)

Summary

Recognizes a protein of 40-45kDa, identified as human milk fat globule membrane protein (HMFG). HMFG is present on normal human breast epithelial cells and cell lines derived from breast carcinomas, as well as to the outer surface of the human milk fat globule. HMFG is considered as a differentiation marker. It is useful as specific breast epithelial marker and can also provide a tool to study the role of the cell surface in normal and neoplastic mammary development.

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