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Lysozyme (Histiocytoma &Monocytic Acute Leukemia Marker) Antibody [LYZ/3947]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
4069-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4069-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4069-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Lysozyme is an enzyme, commonly referred to as the body s own antibiotic since it kills bacteria.Natural substrate of lysozyme is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species.Lysozyme is synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. This antibody labels myeloid cells, histiocytes, granulocytes, macrophages and monocytes. It is helpful in the identification of myeloid or monocytic nature of acute leukemia.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Secreted
Gene Name
LYZ
Positive Control
Human tonsil, lung or kidney., Spleen
Immunogen
Recombinant fragment of human Lysozyme protein (around aa 18-147) (exact sequence is proprietary)
Alternate Names
Lysozyme C, 1,4-beta-N-acetylmuramidase C, 1 4 beta N acetlymuramidase C; Lysozyme C; LYZ; LYM; Renal amyloidosis

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
LYZ/3947
Chromosome Location
12q15
Mol. Weight of Antigen
17kDa

Functions

  • Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents.

Key References

  • Canfield, R.E., et al. 1971. Primary structure of lysozymes from man andgoose. Nat. New Biol. 232: 16-17.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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