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SDS-PAGE Analysis of Purified L1TD1 Mouse Monoclonal Antibody (L1TD1/7941). Confirmation of Purity and Integrity of Antibody.
Formalin-fixed, paraffin-embedded human placenta stained with L1TD1 Mouse Monoclonal Antibody (L1TD1/7941). Inset: PBS instead of primary antibody; secondary only negative control.
Formalin-fixed, paraffin-embedded human lung stained with L1TD1 Mouse Monoclonal Antibody (L1TD1/7941). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
Formalin-fixed, paraffin-embedded human prostate stained with L1TD1 Mouse Monoclonal Antibody (L1TD1/7941). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
L1TD1 (LINE-1 type transposase domain containing 1), also known as ECAT11 (ES cell-associated protein 11), is an 865 amino acid protein that belongs to the transposase 22 family and is encoded by a gene that maps to human chromosome 1p31.3. Chromosome 1 spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
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