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Recombinant IMP-3 Antibody [IMP3/8985R]

Additional information

Catalog Number: 55272-RBM4
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
55272-RBM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
55272-RBM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
55272-RBM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant IMP-3 Antibody

Formalin-fixed, paraffin-embedded human placenta stained with IMP-3 Recombinant Rabbit Monoclonal Antibody (IMP3/8985R) Inset: PBS instead of primary antibody; secondary only negative control.

IMP3 Antibody in Western Blot (WB)

IMP3 Antibody in Western Blot (WB)

Western blot analysis of HEK293T, MCF7, A549 and K-562 cell lysates using IMP3 Recombinant Rabbit Monoclonal Antibody (IMP3/8985R).

IMP3 Antibody in SDS-PAGE

IMP3 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified U3 small nucleolar ribonucleoprotein protein IMP3 Recombinant Rabbit Monoclonal Antibody (IMP3/8985R). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
IMP3/8985R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Nucleus.
Gene Name
IMP3
Positive Control
HEK293T, MCF7, A549, K-562, brain or lung.|Human liver
Immunogen
Recombinant fragment of human IMP3 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (PubMed:12655004). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797).
Key References
  • Bevanda Glibo D, Bevanda D, Vukojevi K, Tomi S. IMP3 protein is an independent prognostic factor of clinical stage II rectal cancer. Sci Rep. 2021;11(1):10844. Published 2021 May 25. doi:10.1038/s41598-021-90513-y
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
55272
SwissProt
Q9NV31
Chromosome Location
15q24.2
Mol. Weight of Antigen
22-70kDa
Alternate Names
U3 small nucleolar ribonucleoprotein protein IMP3, BRMS2, U3 Small Nucleolar Ribonucleoprotein Protein IMP3; BRMS2; MRPS4

Summary

Imp3, also known as BRMS2, C15orf12 or MRPS4, is a 184 amino acid protein that contains one S4 RNA-binding domain and is the mammalian homolog of the yeast Imp3 protein. Localized to the nucleus, Imp3 exists as a component of a heterotrimeric complex consisting of MPP10, Imp3 and Imp4 and, in this complex, plays a key role in early cleavage events during pre-18S ribosomal processing. The gene encoding Imp3 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

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