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IL22RA2 Antibody [IL22RA2/7291]

Additional information

Catalog Number: 116379-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
116379-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
116379-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
116379-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
IL22RA2 Antibody

Formalin-fixed, paraffin-embedded human adrenal gland stained with IL22RA2 Mouse Monoclonal Antibody (IL22RA2/7291). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

IL22RA2 Antibody - Image 2

Formalin-fixed, paraffin-embedded human adrenal gland stained with IL22RA2 Mouse Monoclonal Antibody (IL22RA2/7291). Inset: PBS instead of primary antibody; secondary only negative control.

IL22RA2 Antibody in SDS-PAGE

IL22RA2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Interleukin-22 receptor subunit alpha-2 Mouse Monoclonal Antibody (IL22RA2/7291). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
IL22RA2/7291
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Secreted.
Gene Name
IL22RA2
Positive Control
carcinoma or liver.|colon|Human tonsil
Immunogen
Recombinant fragment (around aa1-200) of human IL22RA2 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
  • Isoform 1 may play a role in establishing and maintaining successful pregnancy.
Key References
  • Xu, W., et al. 2001. A soluble class II cytokine receptor, IL-22Rα2, is a naturally occurring IL-22 antagonist. Proc. Natl. Acad. Sci. USA 98: 9511-9516.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
116379
SwissProt
Q969J5
Chromosome Location
6q23.3
Mol. Weight of Antigen
27 kDa
Alternate Names
Interleukin-22 receptor subunit alpha-2, Cytokine receptor class-II member 10, Cytokine receptor family 2 member 10, Cytokine receptor family type 2, soluble 1, Interleukin-22-binding protein, ZcytoR16, IL 22BP; IL22RA2; Class II cytokine receptor; CRF2-10; CRF2-S1; CRF2X; Cytokine receptor class-II member 10; Cytokine receptor family type 2 soluble 1; IL-22 receptor subunit alpha-2; IL-22BP; IL-22R-alpha-2; Interleukin 22 binding protein; Interleukin 22 Receptor alpha 2; Class II cytokine receptor

Summary

IL-22Rα2 (Interleukin-22 receptor α2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2- soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22Rα2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is 4- to 10-fold higher than that of the membrane-bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22Rα2 prevents the binding to the IL-22 membrane-bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22Rα2 may be important in regulating inflammatory responses. In addition, IL-22Rα2 can be induced by lipopolysaccharides (LPSs).

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