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IL-6 (Interleukin-6), Mouse [MP5-20F3]

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Summary

IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B-cells and T-cells. IL-6 plays a role in host defense, acute phase reactions, immune responses, and hematopoiesis. IL-6 is expressed by T-cells, B-cells, monocytes, fibroblasts, hepatocytes, endothelial cells and keratinocytes.

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Product Properties & Targets

Host
Rat
Species Reactivity
Mouse
Isotype
IgG1
Cellular Localization
Secreted
Gene Name
Il6
Mol. Weight of Antigen
21kDa
Immunogen
Recombinant Mouse IL-6 protein

Database Links

Entrez Gene ID
16193
Unigene
1019
SwissProt
P08505

Additional Information

Clone
MP5-20F3
Chromosome Location
5 B1 (Mouse)

Known Applications & Suggested Dilutions

  • Neutralization Studies (Order Ab without Azide)
  • Flow Cytometry (1-2ug/million cells)
  • Immunofluorescence (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • O'Connell PJ, et al. 2006. Blood 107:1010. (ELISA Capture)
  • Rochman I, et al. 2005. J. Immunol. 174:4761. (Neut)
  • Abrams J, et al. 1992. Immunol. Rev. 127:5. (ELISA Capture, Neut)
  • Abrams J, 1995. Curr. Prot. Immunol. John Wiley and Sons, New York. Unit 6.20. (ELISA Capture)
  • Sander B, et al. 1993. J. Immunol. Meth. 166:201. (ELISA Capture, Neut)
  • Litton M, et al. 1994. J. Immunol Meth. 175:47. (IHC)
  • Finkelman F, et al. 2003. Curr. Prot. Immunol. John Wiley Sons, New York. Unit 6.28. (In Vivo Capture)
  • Starnes HF Jr, et al. 1990. J. Immunol. 145:4185. (Neut)
  • Riedemann NC, et al. 2003. J. Immunol. 170:503. (Neut)

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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